Izvo Zvaunoda Kuti Uzive Nezve Kurara uye Alzheimer's

Ini ndinoshanda mazuva ese kuchengetedza huropi hwangu muchimiro chakanaka. Ndakaverenga, ndinotamba mitambo nevana vangu (Mazwi neShamwari, chero munhu?), Tora zvinowedzera, unozvitumidza. Ini ndinodya chikafu chinosimbisa chikafu chehuropi-kusanganisira iwo omega 3s andakanyora nezvayo nguva pfupi yadarika. Ini zvakare ndinove nechokwadi chekuwana yakawanda yekurara.

Ndiri kushanda nesimba nhasi kuitira kuti kugona kwangu kugona kugara kwakasimba makumi emakore munzira.

Asi kurarama hupenyu hune hutano hakutidzivirire kubva kunetseka pamusoro penjodzi dzenguva refu dzekuziva kudzikira uye neurodegenerative hosha senge dementia. Vazhinji vevarwere vangu vari kufamba nepakati zera vanotaura neni nezve kutya kwavo kwekurasikirwa nendangariro, kujekesa kwepfungwa, uye nekuziva mabasa nezera - uye nezvekunetseka kwavo nezveAlzheimer's kunyanya.

Pane tsvagurudzo nyowani pamusoro pekubatana pakati pehope neAlzheimer yandinoda kugovana newe - tsvagiridzo inodzamisa kunzwisisa kwedu kwekuti kurara kwakashata uye chirwere cheAlzheimer chakabatana sei. Vazhinji vedu tinogona kunge tichiziva, kana kuziva nezvake, mumwe munhu akabatwa neAlzheimer's. Nehurombo, iyo nhamba inoburitsa izvo kunze. Sekureva kweAlzheimer's Association, mumwe munhu muUS anovandudza chirwere cheAlzheimer mumasekonzi makumi matanhatu nemasere. Nhasi, kune mamirioni mashanu nemazana manomwe ezviuru veAmerica vari kurarama nechirwere ichi chetsinga dzedenga — nzira yakajairika yedementia. Pakazosvika 2050, fungidziro inofungidzira kuti nhamba ichawedzera kusvika pamamirioni gumi nemana.

Chii chinokonzera chirwere cheAlzheimer?

Mhinduro yakaoma ndeyekuti, isu hatisati taziva. Masayendisiti ari kushanda nesimba kuti azive zvikonzero zveAlzheimer. Kunyangwe isu tisati taziva nei, chii chatinoziva ndechekuti chirwere chinokonzera matambudziko akakosha munzira iyo maseru ehuropi anoshanda.

Mabhiriyoni emauroni muhuropi hwedu anogara achishanda, achitichengeta tiri vapenyu uye tichishanda. Ivo vanotigonesa kufunga uye kuita sarudzo, kuchengetedza uye kutora ndangariro nekudzidza, kuona nyika yakatikomberedza kuburikidza nemanzwiro edu, kunzwa kwedu kwese kwese kwekunzwa, uye kuzviratidza isu mumutauro uye maitiro.

Masayendisiti anofunga kuti kune mhando dzinoverengeka dzemapuroteni anokonzeresa kudzikiswa kwemasero ehuropi, zvichitungamira kumatambudziko anowedzera zvakanyanya nekurangarira, kudzidza, manzwiro, uye hunhu- izvo zvinoratidza zviratidzo zveAlzheimer's. Maviri eaya mapuroteni ndeaya:

• Beta-amyloid mapuroteni, ayo anovaka kuti aumbe mabara akakomberedza maseru ehuropi.
• Tau mapuroteni, ayo anokura kuita fiber-senge mapfundo-anozivikanwa semanguru-mukati memasero ehuropi.

Masayendisiti achiri kushanda kuti vanzwisise kuti mabara nematanguru zvinobatsira sei kuchirwere cheAlzheimer nezviratidzo zvacho. Nezera, zvakajairika kuti vanhu vagadzire mamwe eaya anovakwa muuropi. Asi vanhu vane Alzheimer vanokudziridza matanda uye tangles muhuwandu hwakakura kwazvo - kunyanya munzvimbo dzehuropi dzine hukama nendangariro uye mamwe mabasa akaomarara ekuziva.

Kune boka rinokura rekutsvagisa rinoratidza kushomeka kwekurara uye kusawana kurara kwakaringana kwakabatana nehukuru hwakawanda hwe beta-amyloid uye tau mapuroteni muuropi. Imwe ongororo yakaburitswa muna2017 yakawana kuti mune vane hutano, vepakati-vakuru vanhu vakuru, kukanganiswa kwekunonoka kurara kwekurara kwakabatana nemazinga akawandisa eabeta-amyloid protein.

Kurara kwemasikati kwakabatana neAlzheimer's-zvine chekuita neprotein inoiswa muuropi

Chidzidzo chakaburitswa-chingori chinoratidza kuti kukotsira kwakanyanya masikati kunosanganisirwa nehupamhi hwebeta-amyloid protein brain inoisa mune vamwe vanhu vakuru vane hutano. Masayendisiti eMayo Clinic akaisa muchidzidzo chavo kupindura mubvunzo wakakura pamusoro pechakakonzeresa: ko kuvaka kweaprote-amyloid protein kunobatsira pakurara zvisina tsarukano, kana kukanganisa kurara kunotungamira mukuunganidzwa kweaya mapuroteni?

Iyo Mayo Clinic yainge yatove nekuenderera mberi kwenguva yakareba yekudzidza nezve shanduko yekuchinja inosangana nekukwegura. Kubva pachidzidzo icho chatove kumhanya, masayendisiti akasarudza vanhu makumi maviri nevaviri, vaive nemakore anodarika makumi manomwe uye vasina dementia, kuti vaongorore hukama pakati pemaitiro avo ekurara uye yavo beta-amyloid protein chiitiko.

Pakutanga kwechidzidzo, ingangoita kota imwe chete — zvishoma kudarika makumi maviri neshanu muzana — yevakuru muboka vakashuma kuti vakarara zvakanyanya masikati.Kunyanya kurara mukati mehusiku, chokwadi, chiratidzo chikuru chekuti hausi kurara zvakakwana usiku — uye chiratidzo chinofambirana nezvinetso zvekurara zvakajairika, kusanganisira kushaya hope.

Kwemakore manomwe, masayendisiti akatarisa varwere 'beta-amyloid chiitiko vachishandisa PET scans. Vakawana:

Vanhu vane hope dzakanyanyisa dzemasikati pakutanga kwekudzidza vaiwanzo kuve nemazinga akakwirisa e beta-amyloid nekufamba kwenguva.

Mune ava vanhu vasina kurara, huwandu hwakakura hwebeta-amyloid kuvaka-yakaitika munzvimbo mbiri dzehuropi: iyo yekumberi cingate uye iyo cingate precuneus. Mune vanhu vane Alzheimer's, idzi mbiri nzvimbo dzehuropi dzinowanzo kuratidza mazinga epamusoro e beta-amyloid anovaka.

Ichi chidzidzo hachipe mhinduro chaiyo kumubvunzo wekuti kana kurara kwakashata kuri kutyaira amyloid protein kuvaka, kana maamyloid deposits ari kukonzera matambudziko ekurara- kana zvimwe zvacho zvese zviri zviviri. Asi zvinoratidza kuti kurara zvakanyanya mukati mezuva kunogona kuva chiratidzo chekutanga chekunyevera nezvechirwere cheAlzheimer.

Chidzidzo cheMayo Clinic chinoenderana nekutsvagurudza kwazvino kwakatarisa hukama pakati pekurara zvisina tsarukano nenjodzi yeAlzheimer. Masayendisiti kuYunivhesiti yeWisconsin, Madison akaferefeta hukama hunogona kuitika pakati pehunhu hwekurara uye mamaki akakosha eAlzheimer's, anowanikwa musipinha mvura, kusanganisira mamaki e beta-amyloid mapuroteni uye mapuroteni etau anotungamira kune tsinga-sero dzinodzedzereka tambo.

Muchidzidzo ichi, masayendisiti akaedza vanhu vasina Alzheimer's kana dementia - asi vakasarudza vanhu vaive panjodzi huru yechirwere ichi, kungave nekuti vaive nemubereki aneAlzheimer kana nekuti vaitakura rimwe geni (apolipoprotein E gene), iyo yakabatana nechirwere.

Kufanana nevamwe vavo kuMayo, vatsvagiri veMadison vakaona kuti vanhu vakasangana nehope dzakanyanya masikati vanoratidza mamwe mamaki eprotini-amyloid. Vakawana zvakare hope dzemasikati dzakabatanidzwa nemamwe mamaki etaini mapuroteni. Uye vanhu vaiti vakarara zvisina kunaka uye vaive nematambudziko akakura ekurara vakaratidza zvakawanda zveaAlzheimer's biomarkers kupfuura vamwe vavo vanorara zvine mutsindo.

Uropi hunozvichenesa kubva pamapuroteni ane chekuita neAlzheimer panguva yekurara

Aingova makore mashoma apfuura masayendisiti akawana nzira yaisazivikanwa muuropi inobvisa marara, kusanganisira mapuroteni e beta-amyloid ane hukama neAlzheimer's. (Yunivhesiti yeRochester Medical Center masayendisiti akaita izvi zvakawanikwa akaitumidza kuti "glymphatic system," nekuti inoshanda zvakanyanya senge lymphatic system yemuviri mukubvisa tsvina mumuviri, uye inoshandiswa nemasero ehuropi ehuropi.) Masayendisiti haana t ingozivisa iyo glymphatic system-inokatyamadza kuwanikwa mairi uye pachayo. Vakawana zvakare kuti iyo glymphatic system inopinda mukunyanyisa panguva yekurara.

Patinorara, masayendisiti akawana, iyo glymphatic system inova kakapetwa kagumi mukubvisa marara kubva muuropi.

Uku ndiko kumwe kwekutsvagisa kwakanyanya asi kuratidza kukosha kwekurara zvine hutano kune hurefu-hurefu hutano hutano. Paunorara, vesaenzi vava kufunga, yako glymphatic system inokwidza chiitiko chayo kubvisa marara anogona kukuvadza akaunganidzwa pamusoro pezuva rako rekumuka. Kana iwe ukarara zvisina kunaka kana kuenda usina kurara kwakaringana nguva dzose, iwe uri panjodzi yekushayikwa pamhedzisiro izere yeiyi yekuchenesa maitiro.

Kusarongeka-kwekurara-wake macirconi akabatana neAlzheimer's

Chimwe chingangodaro chine chekuita nehope-chekutanga chiratidzo chekunyevera cheAlzheimer's? Akavhiringidza maitiro ekurara, sekutsvaga kutsva. Masayendisiti kuWashington University Chikoro cheMishonga akateedzera mitenderedzwa uye kurara-kumuka kweanosvika mazana maviri vakuru vakuru (avhareji zera, 66), uye vakavaedza vese kwekutanga-pre-kiriniki zviratidzo zveAlzheimer's.

Mune varwere makumi mashanu vakaratidza pre-kiriniki zviratidzo zveAlzheimer's, vese vaive vakanganisa kurara-kumuka macircuit. Izvi zvaireva kuti miviri yavo yanga isinganamatire kune yakavimbika nzira yekurara kwehusiku uye chiitiko chemasikati. Ivo vaikwanisa kurara zvishoma usiku, uye vaida kuteedzera kurara zvakanyanya masikati.

Chinhu chakakosha kucherechedza apa: Vanhu vari muchidzidzo avo vaive vavhiringidza kurara-kumuka makwikwi havasi vese vakarara vasina kubatwa. Ivo vaive vachiwana kurara kwakaringana-asi ivo vaive vachiunganidza kurara munzira yakatsemuka zvakanyanya pamusoro pezuva remaawa makumi maviri nemana.

Ichi chidzidzo chinoratidza kuti kukanganiswa kwema circadian mitinhimira inogona kunge iri yekutanga biomarker yeAlzheimer's, kunyangwe mukushayikwa kwekurara.

Kana varwere vangu vachigovana neni kunetseka kwavo nezve kwavo kwenguva refu kwehutano hutano uye kutya kwavo kweAlzheimer's, ndinonzwisisa. Ini ndichakuudza zvandinovaudza: chinhu chakanakisa chaungaite kushandura kunetseka kwako kuita zvekuzvidzivirira uye kuzvitarisira nhasi, nechinangwa chekudzikisa njodzi yako yekudzikira kwekuziva uye kuora mwoyo mupfungwa. Tichitarisa pane zvese zvatinoziva, zviri pachena kuti kuwana hwakawanda, hwemhando yepamusoro kurara chikamu chakakosha cheichi chiito chirongwa.

Hope dzinotapira,
Michael J. Breus, PhD, DABSM
Chiremba Wekurara ™
www.muende.com