Ndeapi Mafambiro Ekufamba Anogona Kuzivisa Nezvokuziva Kuderera

Pfungwa dzakakosha: Tsvagurudzo nyowani muhukama hwakafundwa kwenguva refu pakati pekushanduka kwe gait uye kutanga kwekuziva kwekudzikira uye kuora mwoyo kwakawana kuti kukwira-kuenda-kukwirisa kuchinjika kwainyanya kufanotaura nezvechirwere cheAlzheimer pane kudzikira kwekuziva kwezera.

Tsvagurudzo nyowani inoratidza kuti nhanho-ku-nhanho shanduko munzira yemumwe munhu yekufamba inogona kunge iri nzira nyowani yekuongorora mamwe marudzi ekuziva kudonha kune vakuru vakuru. "Zvatinowana zvinoratidza kuti kukwirira kwakasiyana-siyana chiratidzo chekuziva kusagadzikana, izvo zvinogona kubatsira kuziva chirwere cheAlzheimer's dementia," vanyori vanodaro. Izvi zvakawanikwa (Pieruccini-Faria et al., 2021) zvakaburitswa muna Kukadzi 16 muna Alzheimer's & Dementia .

Iyi yakawanda-cohort "gait uye brain" ongororo yakaongorora kubatana pakati pekufamba uye kugona nekufananidza gait patani kune ese ekuziva masisitimu mune akasiyana siyana evakuru vakuru vane chirwere cheAlzheimer, chirwere cheParkinson, Lewy muviri dementia, frontotemporal dementia, hunyoro hwekuziva kukanganisika, kuzviisa pasi kwekukanganisa kwekuziva, uye nekuziva zvine hutano kudzora boka.

Mushure mekuyedza ina yakazvimirira gait maitiro (kumhanya, postural kudzora, mutinhimira, uye misiyano) pakati pevane mazana mashanu emakiriniki ekuyedza vatori vechikamu kubva kune akasiyana "enisikopu anonzwisisika" macohorts akanyorwa pamusoro, vatsvagiridzi vakaona kuti "chete kwakakwirira gait kusiyanisa kwakabatana nekudzika kwekuziva kwekuita uye yakaratidza chirwere cheAlzheimer ine 70 muzana chaiyo. "

"Kukanganiswa kweGait kunowanzoitika mukusagadzikana kweiyo neurodegenerative. Kunyanya, gait kusiyanisa - iyo nhanho - ku - fambisa kudzikama mune chinhambwe uye nguva - yanga ichibatanidzwa nehutachiona hwehutachiona nekukanganisa kwekuziva," vanyori vanotsanangura mumashoko avo ekutanga. "Zvisinei, kuenzanisa kwehuwandu hwehutachiona hwehutachiwana mukati mekuziva kwepfungwa dzekushomeka hakuna kuongororwa zvakaringana [kusvika zvino]."

"Uhwu ndihwo humbowo hwekutanga hwakasimba hunoratidza kuti kusiyanisa gait chiratidzo chakakosha chezviitiko zvinoitika munzvimbo dzehuropi dzakabatana nekukanganisa kwekuziva pamwe nekudzora mota," munyori wekutanga Frederico Perruccini-Faria weUniversity yeWestern Ontario Lawson Health Research. Institute akadaro mukuburitswa kwenhau. "Takaratidza kuti kukwirira kwakasiyana-siyana kwechiratidzo chechiratidzo ichi-cortical kusagadzikana kunogona kuziva zvakavimbika chirwere cheAlzheimer kana ichienzaniswa nezvimwe zvinokanganisa neurodegenerative."

"Tine humbowo hwakareba hunoratidza kuti matambudziko ekuziva, akadai sekusafunga ndangariro uye kusagadzikana kwepamusoro, anogona kunge ari mafungidziro ekuderera. Iye zvino, tiri kuona kuti mashandiro emota, kunyanya nzira yaunofamba nayo, inogona kubatsira kuongorora mhando dzakasiyana dzemamiriro ezvinhu eurodegenerative," munyori mukuru Manuel Montero-Odasso, purofesa paYunivhesiti yeWestern Ontario uye director weGait neBrain Lab, akawedzera. "Isu tinoona gait kusiana kuve kwakafanana neye arrhythmia. Vanopa hutano vanogona kuyera pamwe nevarwere mukiriniki, zvakafanana nemabatiro atinoita moyo mutinhimira ne electrocardiograms."

Zvitatu zvakakosha kubva pane iyi "Gait neBrain" kudzidza (Pieruccini ‐ Faria et al., 2021)

1. Gait uye kugona kwekuziva kwakabatana zvakanyanya muzvirwere zveeurodegenerative.
2. Yakakwira gait kusiyanisa (stride-to-stride shanduko) inosarudzika chirwere cheAlzheimer kubva pamazera ane hukama nezera neurodegenerative kusagadzikana.
3. Yakakwira gait misiyano inoratidza kugona - cortical kusagadzikana mueurodegeneration.

"Kuwedzera kwe gait kusiyanisa kunogona kuratidza kufambira mberi kwekukanganisa kwekuziva muzvirwere zveeurodegenerative, uye zvingangoita nehunyanzvi hwechirwere cheAlzheimer's dementia, inova archetypal cortical cognitive disorder," vanyori vanopedzisa. "Kudzidza kwedu, nekudaro, kunotsigira pfungwa yekuti, zvichienzaniswa nedzimwe gait parameter, gait kusiyanisa kunogona kunge kuri kuisa mucherechedzo wekuziva-cortical kudzikira mumatambudziko eurourogenerative. Chidzidzo chenguva yemberi uchishandisa boka rekusimbisa chinodiwa kusimbisa zvatakawana."

Mukutevera-kwekutevera, ini ndichaongorora mashandisiro eiyo cerebellum zvave zvichisanganisika neakakwira gait kusiyanisa (Schniepp et al., 2011) uye chinowanzo kufuratirwa chinongedzo pakati pecerebellar atrophy uye chirwere cheAlzheimer (Wegiel et al., 1999; Jacobs et al., 2017).