Iyo Serotonin Transporter Gene uye Kushungurudzika

Zvemukati

• Kushungurudzika Kwakakosha Kuverengwa
• Kana Kushungurudzika Kwaive Hutachiona

Nei vamwe vanhu vachikura zvakanyanya kushungurudzika kusagadzikana uye vamwe vasiri kwakaomarara uye kusinganzwisisike maitiro. Zvinhu zvakati wandei zvakakurukurwa kuti zviwedzere kuora mwoyo, pakati padzo:

Kusiyana kweGenetic: Vanhu vakatakura imwe kana maviri makopi eimwe njodzi anorara pane imwe kana kupfuura "kushushikana kwemajini / s" vane njodzi yakanyanya yekudzikira kushushikana.

Zvemamiriro ekunze: Zviitiko zvehupenyu zvakashata sekushungurudzika, kuregeredza, kana kushungurudzwa zvinowedzera mukana wekushungurudzika.

Gene-ne-nharaunda kudyidzana: Zviitiko zvehupenyu zvisina kunaka zvinongotungamira mukushushikana mune vanhu vane yakasarudzika majini-seti inoita kuti vave nenjodzi-inokasira kukura kushushikana.

Iyo geni inowanzo sangana nekushungurudzika ndeye serotonin transporter geni SLC6A4 (Bleys et al., 2018). Serotonin neurotransmitter inokanganisa kuwanda kwehupenyu maitiro uye kugona kwehuropi mashandiro, pakati pavo manzwiro uye manzwiro, ndosaka zvakabatanidzwa kumatambudziko epfungwa senge kushushikana. Chokwadi, mashoma serotonin mazinga akave akabatanidzwa neakaora mwoyo mweya (Jenkins et al., 2016), uye sarotonin reuptake inhibitors (SSRIs) inosarudzika ndiyo inonyanya kutaurwa antidepressants. SSRIs inovhara iyo reuptake yeserotonin panguva yekutaurirana kwemaseru muuropi, ichiita kuti serotonin iwanikwe, uye nekudaro mune dzidziso inobatsira kudzikisa kushushikana.

Pakati pemitsara iyi, pfungwa yekuti serotonin inotakura geni inogona kukanganisa njodzi yekuremerwa kana kuomarara intuitively zvine musoro. Kunyanya, masayendisiti mazhinji akatarisa pane izvo zvinonzi 5-HTTLPR polymorphism mudunhu rinosimudzira re serotonin transporter gene yekutsvaga mhedzisiro yeiyi geni pane kushushikana. Genetic polymorphism zvinoreva kuti pane imwe nzvimbo mugenome, vanhu vakasiyana vanogona kunge vaine misiyano mishoma muDNA yavo inogona kukanganisa kuti mapuroteni anogadzirwa nerudzi anogona sei kuita basa rawo. Muchiitiko cheiyo 5-HTTLPR polymorphism, pane zvipfupi allele (s) uye yakareba allele (l). Nechekare kumashure kuma1990, vaongorori vakaratidza kuti vanhu vane mairi maviri kana imwe pfupi ma alleles vane mukana wakakura wekushungurudzika kupfuura avo vane marefu marefu alleles, sezvo pfupi pfupi inotungamira mukudzikisira kutaura kweserotonin transporter (Collier et al., 1996) .

Ichi chidzidzo chekutanga chakamutsa kufarira mu5-HTTLPR polymorphism, asi kwete ese emabasa emabasa anogona kuwana kusangana kwakajeka. Muna 2003, kutsvaga kunoratidzika kunge kwakagadzirisa kupokana uku. Mune chidzidzo chakataurwa zvakanyanya, Caspi nevamwe vaaishanda navo vakakwanisa kuratidza kuti mhedzisiro ye5-HTTLPR polymorphism genotype pane kushushikana kwakaongororwa neinonzi kudyidzana kwegene-ne-nharaunda (Caspi et al., 2003). Izvi zvinoreva kuti genotype yaizongova nemhedzisiro kana vanhu vakaiswawo kune mamwe mamiriro ezvakatipoteredza. Kunyanya, masayendisiti akawana kuti vanhu vakaita zvakasiyana nezviitiko zvehupenyu zvinonetsa, zvinoenderana neiyo 5-HTTLPR genotype. Vanhu vane angangoita pfupipfupi varere pane iyo 5-HTTLPR polymorphism vakagadzira zvakanyanya kushushikana zviratidzo kana vakasangana neyakaomesesa chiitiko chehupenyu kupfuura vanhu vane marefu maviri ma alleles. Nekudaro, pasina chiitiko chinonetsa chehupenyu, iyo genotype yakanga isina mhedzisiro pamukana wekuvandudza kushushikana.

Ichi chidzidzo chakawedzera kuwedzera kufarira mu5-HTTLPR polymorphism uye hukama hwayo nekushungurudzika, zvichitungamira kuzvimwe zvidzidzo pamusoro penyaya iyi. Nekudaro, dambudziko rezvizhinji zvezviongororwa izvi ndezvekuti saizi yavo yekuenzanisira yaive yakaenzana padiki kune zvidzidzo zvechibereko, zvingangotungamira mukukanganisa mhedzisiro uye kukundwa kwakanyanya.

Anenge makore gumi apfuura, Risch nevashandi pamwe navo (Risch et al., 2009) vakaita inonzi meta-ongororo, kuwanda kwehuwandu hwezvidzidzo zvehunyanzvi. Vakaongorora zvidzidzo gumi neshanu pa5-HTTLPR polymorphism uye hukama hwayo nekushungurudzika uye kuti hukama uhwu hwakakanganiswa nezviitiko zveupenyu zvinonetsa sezvakange zvataurwa naCaspi et al. (2003). Mhedzisiro yavo yaive yakajeka: Nepo zvimwe zviitiko zvehupenyu zvinonetsa zvakakonzera njodzi yakanyanya yekushushikana, pakanga pasina mhedzisiro yeiyo 5-HTTLPR genotype pane kushushikana uye hapana gene-ne-nharaunda yekudyidzana mhedzisiro pakati pegenotype uye zvinonetsa zviitiko zvehupenyu.

Zvisinei nekuwana uku, mazana ezvidzidzo pa5-HTTLPR polymorphism uye kushushikana zvakaburitswa kubvira 2009 (yesainzi yekutsvaga injini PubMed inonyora zvinopfuura mazana masere ezviuru zvezwi rekutsvaga "5-HTTLPR kushushikana" kutanga kwaMay 2019). Chidzidzo chitsva chakaburitswa naRichard Border nevamwe vaaishanda navo muAmerican Journal of Psychiatry (Border et al., 2019) yakanangana nekugadzirisa gakava pamusoro pekuti kana iyo 5-HTTLPR genotype inobata kushushikana uye kana paine geni-ne-nharaunda. kudyidzana pakati peiyo genotype uye kunetsa zviitiko zveupenyu kamwechete uye zvachose. Kuti vadzivise matambudziko ehuwandu hwezvidzidzo zvakapfuura, ivo vakawana dhata kubva kune akati wandei makuru magene emawadhi akawanikwa kune vaongorori, zvichitungamira kune saizi yekuyera yemazana mazana ezviuru zvevanhu. Mhedzisiro yekuwongorora yaive pachena futi: Pakanga pasina humbowo hwehukama hwehukama pakati pe5-HTTLPR polymorphism uye kushushikana, uye pakanga pasinawo humbowo hwekuti zvinoshungurudza zviitiko zvehupenyu kana mamiriro akashata ezvehupfumi zvinogona kuratidza kusangana kwegene-ne-nharaunda. neiyi genotype.

Izvi, hongu, hazvireve kuti hapana hukama pakati peSerotonin nekushungurudzika (zviripo zviri pachena, sekuratidzwa nekubudirira kwekurapa kweSSRIs), asi inokweretesa rutsigiro kune irikubuda nzwisiso yezvepfungwa genetics: Chirwere chepfungwa chakanyanya maitiro akaomarara angangokanganiswa nenhamba yakakura yehunhu uye husina-majini mhedzisiro. Saka nekudaro, hazvigoneke kuti kusiana kwemajini kwakadai se5-HTTLPR polymorphism ine simba rakakura pakuita kana kwete kwemunhu kukura kushushikana kana chero imwe nzira yechirwere chepfungwa. Yveramangwana psychiatry genetic studies zvinoda kutora kuomarara uku nekuongorora kusiana kwemajini kune iyo genome uye epigenome nekuzvirondedzera kuchirwere chepfungwa (Meier & Deckert, 2019).

Kushungurudzika Kwakakosha Kuverengwa

Kana Kushungurudzika Kwaive Hutachiona