Maitiro eVarume neVakadzi Ekugadzirisa Anotya Ndangariro

NaBongo & Maitiro Vashandi

Vanhurume nevanhukadzi vane mukana wakasiyana wekushungurudzika- nekushushikana kwakanangana nekushushikana senge kushushikana uye mushure mekushungurudzika kusagadzikana kusagadzikana (PTSD), zvidzidzo zvakapfuura zvakaratidza. Semuenzaniso, vakadzi vanokudziridza PTSD kaviri mwero wevarume. Vatsvagiri vanoda kuziva kuti nei izvi zviri izvo.

Chikwata chinokura cheuchapupu chinoratidza kuti vanhurume nevanhukadzi maitiro anotya ndangariro zvakasiyana. Tsvagurudzo nyowani mumakonzo kubva kuchikwata chakatungamirwa ne2016 BBRF Mudiki Muchengeti Elizabeth A. Heller, Ph.D., weYunivhesiti yePennsylvania, inogadza dzimwe nzira dzakabatanidzwa. Kunzwisisa nzira idzi kunogona kubatsira mune ramangwana kuvandudzwa kwepabonde-chaiwo marapirwo ezvinetso zvekushushikana.

Zvakawanikwa munguva pfupi yadarika zvechikwata zvakataurwa pamhepo muBiological Psychiatry muna Zvita 5, 2018. Vanoratidza kuti kudzora jeni kunodaidzwa kuti Cdk5 chinhu chakakosha chinopa musiyano munzira inoita varume nevakadzi kutya ndangariro. Misiyano yakaonekwa mune hippocampus yeuropi, nzvimbo yekurangarira, kudzidza, uye kutarisisa kwenzvimbo.

Dzidziso yekushanduka-shanduka yakagadzira nzira dzakasiyana siyana dzinoshandiswa nemaseru kudzora mashandiro emajini avo - nzira yaanoivhura kana kudzima nayo panguva dzakati. Iyo yekugadzirisa michina inoenderana neCdk5 uye kugadzirisa kwekutya ndangariro kunonzi epigenetic mutemo. Rudzi rwekugadzwa kwemajini imhedzisiro yekugadziriswa kwemolekyuli, anonzi epigenetic mamaki, achiwedzerwa kana kubviswa kubva mukuteedzana kweDNA iyo "inoperetera" majini. Nekuwedzera kana kubvisa epigenetic mamaki, maseru anokwanisa kumisa kana kudzima chaiwo majeni.

Kushandisa mbeva sevadzvinyiriri vevanhu-iyo mbeva uropi hwakafanana zvakanyanya munzira zhinji, kusanganisira maitiro emitemo yemajini- Dr. Heller nevamwe vake vakaona kuti kudzora kwenguva refu kwekutya ndangariro kwakasimba muvanhurume kupfuura vanhukadzi. Icho chikonzero: kuwedzerwa mashandiro eCdk5 muvanhurume, zvinokonzerwa neepigenetic mamaki. Iko kumisikidza kunoitika mumasero etsinga mune hippocampus.

Vachishandisa nzira yeruzivo inonzi epigenetic yekugadzirisa, Dr. Heller nevamwe vaaishanda navo vakakwanisa kutsvaga chinzvimbo chakanangana nevakadzi cheCdk5 activation mukuderedza kudzokororwa kwekutya ndangariro. Izvi zvaive nemhedzisiro yakanangana nevakadzi muketani rezviito zvichitevera kuisirwa kwemajini.

Izvi zvakawanikwa chikamu chekunzwisisa kwedu kuri kukura kwekusiyana pabonde mu biology yekuti zviitiko zvinotyisa zvinorangarirwa sei uye zvinoratidza kuti nei bonde riri chinhu chakakosha muhuropi uye hunhu hunhu hunosanganisira kutya uye kushushikana, senge PTSD, kushushikana, uye kusagadzikana.