Kukura Kunoshanda Ropa-Brain Chipingaidzo

NaBongo & Maitiro Vashandi

Vanotsvagurudza vakatungamirwa na2016 BBRF Mudiki Mucherechedzi Ethan Lippmann, Ph.D., vanotaura kuti vakabudirira "kuvaka" nyama yemhasuru inoshanda senge yakakosha dziviriro yehuropi, inonzi chipingaidzo cheropa-chepfungwa. Chipingamupinyi chinoita sesefa inosarudza, ichichengeta mamorekuru mahombe kusanganisira mabhakitiriya kubva muuropi uye musana, asi ichibvumira okisijeni, glucose nezvimwe zvinhu zvakakosha kuti zvipinde.

Basa racho, rakaitwa paVanderbilt University uye rakaburitswa Kukadzi 14, 2019 muStem Cell Reports, rinofanirwa kubatsira kukurumidza kushandurwa kwemazano esainzi mukutsvaga pane huropi.

Nepo maviri-mativi ehuropi-maseru tsika akakwidziridzwa munguva yakapfuura, ino inguva yekutanga mhando-yemhando nhatu inoshanda senge reropa-rehuropi mharadzi rakagadzirwa. Iyo modhi inokura kubva kumasero akatorwa kubva pavanhu vasculature ayo anofambiswa kuti agadzirise zvakare seakasarudzika sero mhando iyo ndiyo hwaro hweropa-huropi chinodzivirira. Ipapo ivo vakaunganidzwa mune matatu-mativi matrix iyo inoshanda senge scaffold.

Iyo cell-reprogramming maitiro, akapayona mukutsvaga kwehuropi neBBRF vanopa uye nevamwe mumakore gumi apfuura, inonzi iPSC, iyo inomirira "indururipotent stem cell" tekinoroji. Iyo ine akawanda mashandisirwo pamushonga, kunyanya mukugadzirwa kwemhando dzakasiyana dze "organoids" - mupenyu, matatu-mativi tsika dzemaseru akabatanidzwa kuti agadzirisezve semasero-mhando akasanangana nenhengo dzakasiyana dzemuviri. Imwe nzira inovimbisa kuenda kumberi mukuedzwa kwezvinodhaka uye kutsvagisa chirwere iri mukugadzira organoid modhi yenhengo dzevanhu, kuona kushanda uye kugona kwemishonga.

Nepo vaongorori vakaedza nehuropi hwehuropi organoids, iyo nzira nyowani yekugadzirisa zvivakwa zvinoita basa reropa remunhu-huropi, kana ikaiswa muuropi organoids, yaizounza sainzi nhanho huru padhuze nekugadzira "uropi mudhishi" iyo yakatendeka tevedzera zvese chimiro uye mashandiro ehuropi chaihwo hwevanhu, kana zvikamu zvacho.

Kudzokorora endothelial barrier muuropi organoids kwakakosha, nekuti huropi hunofanirwa kuchengetedzwa kubva kuzvinhu zviri muropa.

Iyo yeropa-uropi chipinga chinotanga "kubuda" mune zvimwe zvirwere, kusanganisira zvimwe zvirwere zvetsinga zvinosanganisira ALS uye pfari. Izvo zvakare zvinokwanisika kuputika apo kuzvimba mumuviri kunosvika pakakwirira. Iyi inogona kunge iri imwe nzira umo mamorekuru ekuputira anopinda muuropi uye kukanganisa zvakajairika basa, semuenzaniso mune dzakawanda sclerosis.